Detection of HIV type 1 mutations on the pol region in untreated patients in Northern Vietnam: determination of drug resistance and subtypes
نویسندگان
چکیده
Purpose of the study The first antiretroviral therapy was introduced in Vietnam in 1990 and included two nucleoside reverse transcriptase inhibitors (NRTIs). More recently, nonnucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs) were available, particularly through different programmes. In this context, it is interesting to survey the HIV drug resistance and also to determine the main subtypes circulating in this country.
منابع مشابه
Drug- Resistance- Associated Mutations and HIV Sub-Type Determination in Drug-Naïve and HIV-Positive Patients under Treatment with Antiretroviral Drugs
Abstract Background and Objective: Resistance to antiretroviral agents is a significant concern in clinical management of HIV-infected individuals. Resistance is the result of mutations that develops in the viral protein targeted by antiretroviral agents. Material and Methods: In this cross-sectional study, the blood samples of 40 HIV-positive patients were collected. Twenty of them were d...
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To evaluate HIV-1 drug resistance-associated mutations among drug-naive HIV-1-infected patients in Northern Vietnam, we performed sequence analysis of HIV-1 pol-PR and pol-RT in samples collected from 206 (161 men and 45 women) consenting patients in 2008. From these 206 samples, we successfully sequenced 173 pol-PR and 155 pol-RT genes. Phylogenetic analysis revealed that all patients were inf...
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Objective. The increased use of antiretroviral therapy (ART) has reduced the morbidity and mortality associated with HIV, adversely leading to the emergence of HIV drug resistance (HIVDR). In this study we aim to evaluate the prevalence of HIVDR mutations in ART-naive HIV-1 infected patients from northern India. Design. Analysis was performed using Viroseq genotyping system based on sequencing ...
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عنوان ژورنال:
دوره 13 شماره
صفحات -
تاریخ انتشار 2010